Blar i forfatter "Buonocore, Giuseppe"

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    • Culture-negative early-onset neonatal sepsis - at the crossroad between efficient sepsis care and antimicrobial stewardship 

      Klingenberg, Claus; Kornelisse, Rene F.; Buonocore, Giuseppe; Maier, Rolf F.; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-09)
      Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of symptoms are suboptimal. Clinical suspicion therefore frequently leads to empirical antibiotic therapy in uninfected infants. The incidence of culture confirmed early-onset sepsis is rather low, around 0.4–0.8/1000 term ...